Ask your doctor about your specific risk. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Talk to your doctor if you will be breast-feeding a baby during your treatment with isoniazid. This medicine can pass into breast milk, but it will not treat or prevent tuberculosis in the nursing infant.
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.
Isoniazid will not treat a viral infection such as the flu or a common cold. Your doctor may have you take extra vitamin B6 while you are taking isoniazid. Take only the amount of vitamin B6 that your doctor has prescribed. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include vomiting, severe dizziness or drowsiness, slurred speech, blurred vision, hallucinations, trouble breathing, increased thirst, increased urination, fruity breath odor, or loss of consciousness.
You may need to avoid certain foods while you are taking isoniazid. This includes red wine, aged cheese, dried meats, and tuna or other types of fish. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Discussion TRUST will define the physiologic role of alcohol use on TB treatment outcomes independent of its behavioral effects, thus introducing a new paradigm of how to craft interventions to improve outcomes for this population.
Additional File 2: 13K, docx Ethical approval reference numbers. Acknowledgements The authors thank our study team, DOT workers and study participants without whom our work would not be possible. Availability of data and materials Full protocol can be found in the Additional files 1 and 2.
Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Contributor Information Bronwyn Myers, Email: az. References 1. Global Tuberculosis Report The association between alcohol use, alcohol use disorders and tuberculosis TB.
A systematic review. BMC Public Health. Tuberculosis and excess alcohol use in the United States, Int J Tuberc Lung Dis. Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study. Does alcohol consumption during multidrug-resistant tuberculosis treatment affect outcome?.
A population-based study in Kerala, India. Ann Am Thorac Soc. Alcohol exacerbates murine pulmonary tuberculosis. Infect Immun. The impact of alcohol on BCG-induced immunity against Mycobacterium tuberculosis. Alcohol Clin Exp Res. Liang Yan, Harris Frank L. BioMed Research International. T cells and adaptive immunity to Mycobacterium tuberculosis in humans.
Immunol Rev. Alcohol Res. Opposing effects of alcohol on the immune system. Prog Neuro-Psychopharmacol Biol Psychiatry. Meta-analysis of clinical studies supports the pharmacokinetic variability hypothesis for acquired drug resistance and failure of Antituberculosis therapy. Multidrug-resistant tuberculosis not due to noncompliance but to between-patient pharmacokinetic variability.
J Infect Dis. Clin Infect Dis. Tuberculosis trials consortium: association between acquired rifamycin resistance and the pharmacokinetics of rifabutin and isoniazid among patients with HIV and tuberculosis. Effects of ethanol on intestinal absorption of drugs: in situ studies with ciprofloxacin analogs in acute and chronic alcohol-fed rats. Effects of ethanol on intestinal absorption of drugs. Probl Tuberk. Lester D. The acetylation of isoniazid in alcoholics. Q J Stud Alcohol. Unchanged acetylation of isoniazid by alcohol intake.
Low serum antimycobacterial drug levels in non-hiv-infected tuberculosis patients. Pretoria; ;P Imtiaz Sameer, Shield Kevin D. Alcohol consumption as a risk factor for tuberculosis: meta-analyses and burden of disease.
European Respiratory Journal. Burden of fetal alcohol syndrome in a rural west coast area of South Africa. S Afr Med J. Comparison of baseline drinking practices, knowledge, and attitudes of adults residing in communities taking part in the FAS prevention study in South Africa. Afr J Drug Alcohol Stud. Timeline follow-Back. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements.
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What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names Brand names of combination products. Other uses for this medicine. What special precautions should I follow? Before taking isoniazid, tell your doctor and pharmacist if you are allergic to isoniazid, any other medications, or any of the ingredients in isoniazid tablets or oral solution.
Ask your pharmacist for a list of the ingredients. Be sure to mention any of the following: acetaminophen Tylenol , antacids, carbamazepine Carbatrol, Equetro, Tegretol, others , citalopram Celexa , escitalopram Lexapro , fluoxetine Prozac, Sarafem, Symbyax , fluvoxamine Luvox , ketoconazole Nizoral , paroxetine Paxil , phenytoin Dilantin, Phenytek , sertraline Zoloft , theophylline Elixophyllin, Theochron, Theo , and valproic acid Depakene, Depakote.
Many other medications may interact with isoniazid, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. If you become pregnant while taking isoniazid, call your doctor. Isoniazid may cause side effects.
Symptoms of overdose may include the following: nausea vomiting dizziness slurred speech vision problems. What other information should I know? Brand names. Brand names of combination products.
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