This network makes up a large part of the central nervous system , so the research team believes that VLRs can help carry drugs to the brain, boosting the effectiveness of treatments for brain cancer , brain trauma, or stroke.
We believe it could be applied as a platform technology across multiple conditions. The researchers tested their hypothesis on mouse models of aggressive brain cancer , and they report their results in the journal Science Advances. Normally, drugs will not easily penetrate the brain because it is protected by the brain-blood barrier, which stops potentially harmful agents leaking into the brain. However, this barrier also prevents the medication from reaching its target. In the current research, the investigators were interested in testing the effectiveness of VLRs, taking advantage of the disruption of the brain-blood barrier in the case of glioblastoma, an aggressive form of brain cancer.
The research team worked with mouse models of glioblastoma, treating them with VLRs bound to doxorubicin, a drug used to treat this form of cancer in humans. Shusta and colleagues report that this approach was promising, prolonging survival in the rodents treated with this experimental combination.
The investigators note that binding VLRs to various drugs may have another important benefit — it could allow specialists to deliver significantly higher doses of those drugs to the brain ECM. John Kuo. However, since VLRs target the ECM that surrounds brain cells, this could allow the drugs to act on the cells for more extended periods.
Finally, the researchers note that the VLRs freely circulated through the body in the mouse models, but they did not accumulate in healthy tissue. This suggests that these molecules would not disrupt healthy, functioning organs. Going forward, the investigators want to try combining VLRs with other types of anti-cancer drugs, including those used in immunotherapy, to see how well the molecules would work with a more diverse array of therapies.
Another possibility that the researchers would like to investigate is that of using VLRs to detect any disruptions of the blood-brain barrier, which might indicate the onset of a health event.
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